School of Molecular Sciences

Postgraduate research profiles

Contact

Nikki Man

Phone: (+61 8) 6488 4477


Start date

Jan 2013

Submission date

Aug 2016

Nikki Man

Nikki Man profile photo

Thesis

The investigations into the synthesis and biological mode of action of novel antibacterial agents.

Summary

The main aim of this project will be to establish a pharmacological study for a novel antibacterial compound, defining parameters such as susceptibility to pathogenic organisms, its structure-activity relationship and its mechanism of action.

Why my research is important

A major public health problem that our society is currently facing is the growing trend in antimicrobial resistance. It has been documented that the percentage incidence of methhicillin-resistant Staphylococcus aureus (MRSA) infections has increased from 5% in 1980 to 50% in 2000.[1] This pandemic is placing significant pressure on health care systems around the world [2] as infections caused by these pathogens are causing increased levels of morbidity and mortality than observed in the past century.[3] Due to increasing antimicrobial resistance, the number of currently available antimicrobial treatment choices for more serious bacterial infections is steadily decreasing.

References:

[1] Schmidt, M., Beyond Antibiotics: Strategies for Living in a World of Emerging Infections and Antibiotic-Resistant Bacteria, North Atlantic Books: (2009).

[2] Theuretzbacher, U., International journal of antimicrobial agents, (2012) 39, 295.

[3] Projan, S. J.; Bradford, P. A., Curr. Opin. Microbiol., (2007) 10, 441.

Funding

  • Australian Postgraduate Award
  • University of Western Australia Safety Net Top-Up