School of Molecular Sciences

Postgraduate research profiles

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Guangzhen Zhao


Start date

Aug 2012

Submission date

Aug 2015

Curriculum vitae

Guangzhen Zhao CV
[doc, 135.47 kb]
Updated 30 Jan 2013

Guangzhen Zhao

Guangzhen Zhao profile photo

Thesis

Chiral Sulfoxide Ligands: Synthesis and Applications in Hydroboration Reactions

Summary

The aim of this project is to investigate the facile synthesis of a group of chiral sulfoxide compounds and use them as chiral ligands in asymmetric hydroboration reactions.

Why my research is important

In the last 20 years, chiral sulfur ligands have been sporadically studied. In the case of sulfoxides, the inherent stereogenic center at the sulfur and the close vicinity of it to the transition metal center in precatalysts may lead to unprecedented reactivity patterns in the enantiofacial discrimination. The organoboranes produced from alkenes, especially the ones containing stereogenic carbon centers, are important intermediates and synthons for many natural products, functional groups and drug synthesis. They are often used to form carbon-oxygen, carbon-nitrogen, carbon-carbon, boron-carbon, boron-chlorine bond consecutively.

Funding

  • funding of the group, funding from The University of Western Australia